Isaiah 40 gives an awesome picture of Who God is – attributes that I don’t think we focus on enough in worship.
The first 11 verses are referred to often, because they include prophecies foretelling John the Baptist (v3) and the coming of Jesus (v5, 9-10). These verses characterize God in ways we appreciate: comfort (v1), speaking tenderly (v2), His enduring Word (v8), a powerful ruler with rewards for those who follow Him (v10), and a gentle, caring shepherd (v11).
However, the middle verses of this chapter point out other attributes of God that we would be wise to remember, meditate on, and worship Him for. Many of these verses remind me of how God answered Job (in the book of Job) when he was bold enough to question God for allowing him to suffer.
In Isaiah 40:12-14 and 25-26, God presents several rhetorical questions, making the point that only God has the power and breadth of knowledge to create and control the universe. God then contrasts His greatness and eternal nature with mankind. No matter how great any given nation may become, it is still quite temporary and insignificant compared to God (v15, 17). How much smaller, then, are individuals compared to the greatness of God (v22-24). Clearly, no one compares to God (v25). When we consider the greatness of God, and our insignificance in comparison, it can understandably lead us to wonder if God even cares about us, collectively or individually (27).
The end of the chapter (v28-31) not only gives hope, but I think it shows why it’s important to keep in mind how much greater God is than we are. It is because of God’s greatness, because He is everlasting and does not grow tired, that when we struggle, when we grow tired, when we humble ourselves and look to God for help, we can be confident He willing and more than capable to help us. This is the God we worship!